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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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PCOS, No Periods, Weight Loss, Enlarged Breasts, Trying To Conceive. Taking Metformin. Pregnant?

I have PCOS , and am on metformin 1500mg, been taking for 7mths. I am 220lbs @ 5 7, and have lost 70 lbs in 9mths. Have not had a period for 6mths. My breasts have gotten larger and fuller, in the past 6-8wks. They are larger now than they were when I weighed 285. I have been TTC for over a yr. Is the increase in breast size due to the metformin? Is there a possibility that I can be pregnant without having a period?
Fri, 4 Apr 2014
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OBGYN,  's  Response
Hello
Thanks for writing to us with your health concern.
Generally speaking, Metformin is not associated with any kind of changes in the sizes of the breasts.
With PCOS, irregular cycles are the norm.
More often than not, there are prolonged periods of amenorrhoea.
Weight loss is a must, the loss you have had is commendable, but more is needed.
Please have a complete workup for PCOS.
This will include a pelvic ultrasound scan .
Also, hormonal levels - FSH, LH,TSH, Prolactin, OGTT, DHEAS, Serum free testosterone, Lipid Profile.
Next, take a pregnancy test to rule out pregnancy conclusively
WIth PCOS, ovulation is erratic and hence it is better to rely on a blood pregnancy test.
Yes, since ovulation is erratic, you can conceive even during supposed periods of amenorrhoea.
Take regular folic acid supplements as you are TTC.
All the best
Please feel free to discuss further.
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PCOS, No Periods, Weight Loss, Enlarged Breasts, Trying To Conceive. Taking Metformin. Pregnant?

Hello Thanks for writing to us with your health concern. Generally speaking, Metformin is not associated with any kind of changes in the sizes of the breasts. With PCOS, irregular cycles are the norm. More often than not, there are prolonged periods of amenorrhoea. Weight loss is a must, the loss you have had is commendable, but more is needed. Please have a complete workup for PCOS. This will include a pelvic ultrasound scan . Also, hormonal levels - FSH, LH,TSH, Prolactin, OGTT, DHEAS, Serum free testosterone, Lipid Profile. Next, take a pregnancy test to rule out pregnancy conclusively WIth PCOS, ovulation is erratic and hence it is better to rely on a blood pregnancy test. Yes, since ovulation is erratic, you can conceive even during supposed periods of amenorrhoea. Take regular folic acid supplements as you are TTC. All the best Please feel free to discuss further.