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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Should The Combivir PEP Prescription Be Started Now Or In The Morning?

I just filled out a Combivir PEP prescription. I am 34 hours from exposure and I hear it works best within 36 hours. However, I also hear it needs to be taken regimentally in the morning with breakfast and again at night with dinner. I dont know if I should start now or in the morning (it is 12:47am here)
Mon, 15 Sep 2014
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General & Family Physician 's  Response
Hello
Combivir is combination of Zidovudine + lamivudine and prescribed after meal early in the morning and after dinner ,because on empty stomach it is very difficult to tolerate these drugs because of GI discomfort and acidosis .
But in your case you should not wait for morning .
Take this drug at once after some meal and next dose you can take after 8-10 hours and so on .
Within 2 days dosage will adjust.
Hope this will help you.
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Should The Combivir PEP Prescription Be Started Now Or In The Morning?

Hello Combivir is combination of Zidovudine + lamivudine and prescribed after meal early in the morning and after dinner ,because on empty stomach it is very difficult to tolerate these drugs because of GI discomfort and acidosis . But in your case you should not wait for morning . Take this drug at once after some meal and next dose you can take after 8-10 hours and so on . Within 2 days dosage will adjust. Hope this will help you.