Dear Friend. Nice to see your concern for your friend. She has multiple problems. As you said that she also developed kidney dysfunction, that you are supposing to be because of gabapentin. But i must bring into your notice, that she is taking Celebrex(celecoxib), which is an Non Steroidal Anti inflammatory Drug (NSAIDs) , which causes renal failure and also causes increase cardiovascular problems and mortality. And to add to your knwldge, it is not an anti coagulant. Moreover, since NSAIDs also leads to peptic ulcers and upper gastro intestinal bleed, she is on high risk for that with serious consequences as she must be recieving anti coagulant. My advise is to STOP Celebrex immediately. Now the pain part is difficult to manage as she can t take NSAIDs and she feels depressive with opiods. She can try capsaicin gel locally. If she has worse pain , she can apply topical NSAIDs like volini gel.. as they are comparitively less harmful. There is a drug called as Flupirtine, which is a centrally acting non - opiod analgesic. However not totally safe in renal impairment, but still can be used. Stay Healthy. Dr Anshul, MD