Hello Welcome to Ask a Doctor service. I have reviewed your query, and here is my advice. The allopathic agents (Antidiabetic agents) like biguanide and other classes is the best antidiabetic agents besides these several other molecules are available which reduces the blood sugar, and it has been given according the type of diabetes and blood glucose status, in my opinion above mentioned molecules is most advisable (Metformin, Glibenclamide, Glimepride and others ) these can be given in combinations and give excellent result in diabetes. Hope I have answered your query, let me know for further assistance.