Hello, Welcome to healthcare magic. I understand from your query that you are concerned about the long term side effects of depiwhite cream. Depiwhite is a cream used to lighten hyperpigmentation and not to improve the general complexion. Your skin tone is determined at the time of your birth itself and it is decided by the concentration of melanocytes and circulation. Therefore any treatment or procedures can never make you fairer than what you were at the time of birth. But most of the people will acquire more pigmentation as age increases, we call it facultative pigmentation. Lot of factors determine it, most important being sunlight, others include dust, pollution, smoking, less hydration, intrinsic ageing and free radical damage, stress etc. Treatments should be to bring your pigmented skin back to your normal skin tone and make the skin tone even all over the face. Depiwhite contains hydroquione which is a potent bleaching agent. Though its association with cancer is controversial, it is well known to cause side effects like rebound pigmentation and ochronosis . Rebound pigmentation, as is self explanatory is recurrence of pigmentation after prolonged use. To prevent this, you need to maintain its effect and prevent darkening using a sunscreen and other agents like Kojic acid and vitamin C. Ochronosis is a less common side effects and occurs due to deposition of a brownish black pigment in the skin after prolonged use of hydroquinone. This is very difficult to get rid off once it develops. Hence I suggest you to use a face wash twice a day ideally a one containing glycolic acid as it helps in exfoliation and to even out the skin tone. You may consult a dermatologist practicing cosmetology for few sittings of chemical peels for faster improvement. Hope this helps you. Take care.