Some women, especially those not having hot flashes, use topical estrogen to treat the skin. While usually this is used on the vulva and vagina, there are estrogen receptors all over the body, including the skin, and many women use a little on their face to decrease wrinkling and promote fuller more elastic skin. Estradiol cream is expensive but a single tube should last over a year if used that way (off label which means not FDA approved). A weaker estrogen, estriol, can be compounded, may be less expensive, and also help the skin. Either of those require a prescription. Natural estrogen is a marketing term. Both of the estrogen preparations I mentioned above are naturally occurring, made by your own ovaries during the reproductive years, and in smaller amounts throughout your life. Some of the medications are derived from soy, but most come from wild yam plants. There is also an equine (horse derived) estrogen cream on the commercial market-no wheat or soy-made from pregnant mare urine and brand named premarin. There are plant-like estrogens in red clover, soy, wild yam, black cohosh and some other botanicals, but they have been studied and do not have much if any action on the human estrogen receptors. Most of the health food marketed estrogens obtainable without a prescription fail to help consumers, but do a good job making money for their manufacturer. Keep in mind natural is not always best. You brushed your teeth and probably put on deodorant this morning. Tooth decay and body odor are natural. You have lived beyond the average life expectancy for women only a generation ago. I m glad you look good and feel well. Be careful of the difference between marketing and medicine. There are no over the counter plant like estrogens that will help decrease wrinkling and increase stretchiness of the skin.