Suggest The Dosage Period For TB Medicines

please tell me the right timings to take tb medicines AKT4. My husband 40 yrs of age who had under gone low anal fistulla operation came to know that it was due to tuberculosis from the biopsy test. Actually he has started taking medicine 3 weeks back. But the problem is each time he is visiting for review there is a different doctor and he is giving different time of the day; to take the same medicine.Now my hubby is taking rifampicin on empty stomach, pyrazinamide {2 tabs} immediately after breakfast and ethambutol hydrochloride+ isoniazid tablet immediately after lunch and finally benadone at the bedtime.but another doctor advised to take all the four on empty stomach and another doctor advised to take rifampicin on empty stomach and the other 3 immediately after break fastSo please tell me the right time to take the medicine and can he change the timings now with out any risk Thanking you