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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest The Withdrawal Procedure For Premarin

I am 72 yrs old, have been on premarin since age 32 due to complete hysterectomy. Have tried 8 different times to come off but in the almost third month, I get so sick I cant function normally. I am now on. 3 Mg. I am 72 years old now. What is my problem?
Tue, 22 Dec 2020
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General & Family Physician,  's  Response
Hi,

Premarin contains the hormone estrogen in the form known as conjugated estrogens which is a type of treatment called hormone replacement therapy. Premarin helps to relieve the discomfort many women feel during and after menopause, including symptoms like hot flushes, sweating and dryness. If the plan involves going off or stopping hormones like Premarin, then typically this should be a gradual process over a period of time.

The most common recommended withdrawal procedure for Premarin is as follows:

1. Reduce Premarin daily dosage to next lower level every 2-4 weeks until the lowest dosage is reached.
2. If lower estrogen symptom becomes significant, maintain current dosage for several weeks and if necessary, increase it to next highest dosage for 2-4 weeks.
3. Once the lowest dosage is reached, then alternative days on treatment and off treatment.
4. While weaning or stopping, use Progesterone Cream or non hormonal alternatives if possible, such as vitamin E and soy protein foods and if necessary, herbal supplements like Promensil or Remifemin.

But, stopping Premarin gradually should be done under the supervision of a specialized physician.

Take care. Hope I have answered your question. Let me know if I can assist you further.

Regards,
Dr. Zubayer Alam, General And Family Physician
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Suggest The Withdrawal Procedure For Premarin

Hi, Premarin contains the hormone estrogen in the form known as conjugated estrogens which is a type of treatment called hormone replacement therapy. Premarin helps to relieve the discomfort many women feel during and after menopause, including symptoms like hot flushes, sweating and dryness. If the plan involves going off or stopping hormones like Premarin, then typically this should be a gradual process over a period of time. The most common recommended withdrawal procedure for Premarin is as follows: 1. Reduce Premarin daily dosage to next lower level every 2-4 weeks until the lowest dosage is reached. 2. If lower estrogen symptom becomes significant, maintain current dosage for several weeks and if necessary, increase it to next highest dosage for 2-4 weeks. 3. Once the lowest dosage is reached, then alternative days on treatment and off treatment. 4. While weaning or stopping, use Progesterone Cream or non hormonal alternatives if possible, such as vitamin E and soy protein foods and if necessary, herbal supplements like Promensil or Remifemin. But, stopping Premarin gradually should be done under the supervision of a specialized physician. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Zubayer Alam, General And Family Physician