I am taking a 5 day course of oral prednisone total 40 mg each day. I take trazodone 50 mg qhs. I just took my first dose several hours ago. I notice a bit of chest tightness, like I want to take deeper breaths. Doctors always comment that my heart and lungs are excellent, though I did take this prednisone for a tenacious allergic inflammation in mucous membranes back of throat, neck level irritation, and sensation of irritation in upper lung fields (nothing on xray; also checked out for infection, none) following a cold. Could this be an interaction or a side effect of prednisone?