Hello, Estrogen withdrawal causes symptoms like depression, anxiety and difficulty in sleeping. Using estrogen is not really safe because it leads to a high risk of getting deep vein thrombosis, pulmonary embolism and stroke. Instead you can use a very low dose antidepressant. My suggestions are as follows: 1) Usually, 2–6 weeks of anti-depressants at a therapeutic-dose level are needed to observe a clinical response. 2) Take tab. Lexapro 10mg once daily for 2 weeks and then you can increase it to 20 mg per day. 3) It is an antidepressant that is well tolerated. 4) Onset of depression relief may occur after 1-2 week, but individual responses vary, and a full effect may not be seen until 8-12 weeks. 5) Daily meditation for 5 mins a day is recommended. 6) Physical exercise for atleast 30 min a day is helpful battle with anxiety. 7) Spending more time with kids and pets also helps in reducing anxiety and improves the mood. If you don t see any effect even after 3-4 weeks, you can consult a psychiatrist in person for further evaluation. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Pallavi M., Anesthesiologist