Hi, Thanks for writing in. Kidney is an organ which filters the blood of impurities like blood urea and creatinine. It is important to know that kidneys are important for the proper functioning of the human body. Any obstruction to urinary flow might damage the kidney. Kidney damage also occurs due to strong medicines given during chemotherapy. Chronic conditions like diabetes and high blood pressure also cause kidney impairment. It is important to know the underlying cause of kidney dysfunction in you uncle. Serum creatinine level slowly increases and 8 is high. It would not have occurred suddenly in a prostate cancer patient and earlier reports are to be reviewed and please discuss the same with his doctor. In emergency he might go for a hemodialysis and subsequently measures are to be taken to maintain the level of serum creatinine. His diet also needs to be controlled and fluid intake monitored as recommended. Please do not worry.