Suggest Treatment For Neuropathy And Loss Of Appetite

my grandfather is 75 years old, and has DM since past 30 yrs, i am very worried for him from last one year he is bed ridden, walks but with assistance, has retinopathy, neuropathy and has loss of appetite and has become very lean, he also has CVS problem pls let me know what to do? he is taking CARDACE, LASIX, PLAVIX, INSULIN