What causes night sweats that have a sour odor? I am 47, female, surgical menopause 11/2013. These night sweats are new the past 1-2 months. I also have debillitating fatigue, headache, nausea, excessive weight gain, shortness of breath and lightheadedness. I have been through numerous diagnostic tests the past 2 months. Thyroid is borderline low, low cortisol, possible reactivated EBV.