Hello Dr. I have a dull persistent pain underneath my left rib cage. Not off to the side, but a little more centralized. It hurts to push on it. It may be of interest that I have lupus, a muscle disease, chronic lymphocytic leukemia, and some heart issues. I am taken care of by multiple doctors. This is a new symptom. Oh, I also have IBS. I just don t know what organ could be in that area. I am a 58 year old female. Thanks for considering my question. Yours truly lovelily