Brief Answer: IBS with Spastic Colon with pain in left lower quadrant Detailed Answer: Hi Dear !! Thanks for your query to HCM. I reviewed facts of your query in context to your health issues. My Opinion- In My opinion, in the given situation your father has option of using DBS-Deep brain Stimulation- by- implanted electrodes controling the defective movements caused from degenerated basal ganglion region of midbrain. Dear, yes,P.D.(parkinson s disease) has no treatments in later stages as the medicines which increase dopamine-MAO inhibiters-loose their effectiveness,as the basic defect is -that PD is degenerative disease of brain. Pemvanserin is new entry medicine without dopamine dependence like in MAo inhibiters.Carbidopa if not tried also has better results for few yrs. But the final answer with better quality life is possible with DBS with self nerve implant neurosurgery at special centers in Uk. DBS with peripheral nerve implants from patients peripheral nerve is lately been under consideration in Uk,as this is allowed from FDA lately. For this you would need to Consult Neurosurgeon and plan it, if you desire so. xx. If you update more information/ details upon these suggestions,I would give further suggestions on medicines to correct your health issues. If need be, update any health issue 24 x 7 by a direct question to ME, at following HCM link-http://doctor.healthcaremagic.com/Funnel?page=askDoctorDirectly&docId=70229 Dear,if you don t have any further query in this regard, Do close this query with YOUR pleasing and excellent feedback comments to rate this reply and service, to boost the morale of incoming Emergency patients like YOU, at HCM services. If you want to update more details and ask more update queries , You are most Welcome herewith !! Good Day!! Wishing Good Healthy Life in time to come!! Dr.Savaskar M.N. Senior Surgical Specialist M.S.Genl-CVTS