I have severe itching. I moved from Colorado to Missouri. In CO, my doctor diagnosed me as pre-diabetic & with lesser kidney function . I noticed that my itching dialed down to 0 when I cut way down on sugar foods and drinks. My insurer, Kaiser Permanente is not in MO. Switched to Aetna-Coverntry Gold Advantage. My doctor here noticed a problem using the stethescope. Did an EKG & an echocardiogram. Prescribed Coreg 3.125. Sent me to a cardiologist who prescribed Entresto 24/26 mg. and ordered 2 tests: Cardiac Catheterization and Transesophagel Echocardiogram. Since taking the Entresto, I ve developed itching (without a rash). It s much worse than what I had in Denver. I did some searching on the mayo clinic and web md websites. Out a couple hundred thousand people who were on Entresto, 211 developed itching. I reported this to the doctor s nurse. Her response was keep taking it. After several miserable days, I discontinued it for 2 days. The itching subsided, so I began taking Entresto again. In less than two days I was itching again. I stopped taking the Estresto, but the itching goes on. Neither benadryl (50 mg) taken orally, OTC anti-Itch cream (diphenhydramine Hydrochloride 2%), Zinc acetate,1%, do nothing to relieve the itching. The 2 last tests are not until 17 May. What else can I do to relieve the itching?