Eight years ago I had a bite (tick). Black center, wheel, edema, lasted a few weeks and then slowly resolved. Seven years ago I had bilateral carpal tunnel surgery. I also developed over nite level 8 - 10 pain in knees and ankles. RF was 889. Have been on every RA med since with no results. Now it is getting worse and I have been on Humira for 8 months. I just don t feel good and my mobility and ADL activity poor. My last RF 3 months ago was 543. My PCP and 2 Rheumatologists say there isn t anything they can do for. HELP. I have been a practicing RN for 42 years. I recently went on disability due to the mobility status. I was very active prior and need help to get back to life before. Can you give me any suggestions ? I did have test for Lyme Disease that was negative, and thus ruled-out by the doctors. Thank you, Joann