Hello. Thank you for your question and welcome to HCM. I understand your concern. Heart rate, standardized as normal for the worldwide population, is 60 to 100. There are many changes that happen in the human body during a day that can change this parameter, such as physical activity, hormonal changes and psychological factors. Now, even insomnia or sleep deprivation can cause heart rate to speed up, mainly because of the changes to hormonal peak and nadir levels. There are also caffeine-containing beverages, that can increase the heart rate. Anyway, I am assuming that bisoprolol was prescribed for the blood pressure and to reduce the heart workload, as a measure of prevention. While a safe and effective drug, it does not have marked affect on the heart rate. My recommendation is that you should discuss with your cardiologist for an alternative drug, which also affects the heart rate, by slowing it down. I am referring to other beta-blockers, such as atenolol or metoprolol (although with caution, since you are a diabetic patient) or a drug from the class of calcium channel blockers (e.g. verapamil or diltiazem). I hope I was helpful. Kind regards, Dr. Meriton