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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest Treatment For Weight Loss And Exhaustion In A Person With Macroglobulinemia

My husband has Waldenstrom s macroglobulinemia. The biopsy showed 90% of his cells impacted by the disease. He is losing weight consistently. He started at 162 in January and is now down to 137. He is 72 years old and is very symptomatic - hyperviscosity, enlarged spleen, extreme exhaustion, weight loss, little to no appetite. He has just started having bone pain in his hips, legs and ankles. He is being treated with Rituxan and Velcade. What I want to understand is his prognosis. Our oncologist won t discuss this because he wants to see how he responds to treatment (he s on round 3), but he s obviously deteriorating. What can you tell me?
posted on Mon, 20 Jul 2015
Twitter Thu, 25 Jun 2020 Answered on
Twitter Mon, 29 Jun 2020 Last reviewed on
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General Surgeon,  's  Response
Hello,

As per my clinical experience, the Waldenstrom Macroglubulinemia is not curable, but it is treatable. There are various treatment options as:
- Chemotherapy
- Targeted therapy
- Plasma exchange
- Bone marrow transplant
- Biological therapy

As the condition is deteriorating, that means the systems are not responding to the current therapy regimen. However, if treatment details are available with you, kindly share with me during follow up discussion chat box for better clinical level discussion.

Take care. Hope I have answered your question. Let me know if I can assist you further.



Regards,

Dr. Bhagyesh V. Patel, General Surgeon
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Suggest Treatment For Weight Loss And Exhaustion In A Person With Macroglobulinemia

Hello, As per my clinical experience, the Waldenstrom Macroglubulinemia is not curable, but it is treatable. There are various treatment options as: - Chemotherapy - Targeted therapy - Plasma exchange - Bone marrow transplant - Biological therapy As the condition is deteriorating, that means the systems are not responding to the current therapy regimen. However, if treatment details are available with you, kindly share with me during follow up discussion chat box for better clinical level discussion. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Bhagyesh V. Patel, General Surgeon