45 yr old female. Had first flu shot ever last week. Several hours after had a huge 7cmx 6 cm bullseye wheal that was reddened, hot to touch, itchy, burning followed within 24 hrs by itchy burning scratchy eyes/nose/throat. 24 hrs of benedryl/ice/motrin did nothing. Went to urgent care, given prednisone 60 mg then a 5 day tapering dose. Symptoms subsided greatly in next 24 hrs but systemic symptoms continued several more days. Still have discoloration in area where flu shot was. What on earth was this reaction and why would I have it? Terrified to have another one but it is required at work (I'm an RN). Don't want this to happen again. Could I be allergic to a preservative in the shot?