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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Are The End Stage Symptoms Of Diffuse B Cell Lymphoma Stage 4B?

My daughter has diffuse b cell lymphoma stage 4b, treatment with r chop disease progressed, treatment with r GDP, treatment progressed to cns, treatment with high dose methotrexate has reduced cns cancer but systemic cancer is now growing again. She is 29 years old and will be starting chap next week for 2 cycles and then ?final restaging to determine if strictly palliative care is the only option. What end stage symptoms should we expect?
posted on Fri, 14 Mar 2014
Twitter Tue, 30 Jun 2015 Answered on
Twitter Tue, 30 Jun 2015 Last reviewed on
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Pulmonologist,  's  Response
Thanks for your question on Health Care Magic.
I can understand your daughter's situation and problem.
Diffuse B cell lymphoma is very rapidly progressive in almost all lymphnodes in the body.
It causes lymphnode enlargement and obstruction in the lymphatic channel.
So end stage symptoms can be bilateral lower limb lymphedema, superior vena cavalry syndrome (puffiness of face and breathlessness), weight loss, weakness, anorexia, breathlessness due to Pulmonary embolism and lung metastasis etc.
Opportunistic infections are also common due to lower immunity. So tuberculosis, fungal infection etc are common in end stage of disease.
Hope I have solved your query.
I will be happy to help you further.
Wishing good health to your daughter.
Thanks.
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What Are The End Stage Symptoms Of Diffuse B Cell Lymphoma Stage 4B?

Thanks for your question on Health Care Magic. I can understand your daughter s situation and problem. Diffuse B cell lymphoma is very rapidly progressive in almost all lymphnodes in the body. It causes lymphnode enlargement and obstruction in the lymphatic channel. So end stage symptoms can be bilateral lower limb lymphedema, superior vena cavalry syndrome (puffiness of face and breathlessness), weight loss, weakness, anorexia, breathlessness due to Pulmonary embolism and lung metastasis etc. Opportunistic infections are also common due to lower immunity. So tuberculosis, fungal infection etc are common in end stage of disease. Hope I have solved your query. I will be happy to help you further. Wishing good health to your daughter. Thanks.