Hi, Metoprolol and atorvastatin combination commonly used for treating heart attack and after body effect so it is safe and common side effects will be dizziness fainting drastic reduce in blood pressure if you found any of these kindly contact your doctor as per your description your husband personality has been changed so if you want to start an antidepressant drug or another psychological drug first you should consult psychiatrist whether drug is needed or not and also information about current medicine so your physician and psychiatrist will decide which drug will suit. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Nirav Nimavat, General & Family Physician