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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Are The Side Effects Of Taking Lexapro And Cymbalta Together?

My daughter has been taking lexapro and cymbalta and was having increased cramping and feeling as if she had a cold. Her new doctor was shocked that she was taking both at the same time and advised her to stop taking the lexapro. I have heard of them being taken together, but was unaware of possible dangers to doing so. What are the dangers of taking both at the same time?
Mon, 19 Dec 2016
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General & Family Physician 's  Response
Hi & Welcome.

Taken together they may cause a harmful interaction.

Incomplete data like age, purpose of taking the medications???

Lexapro (Escitalopram) is a selective serotonin reuptake inhibitor (SSRI) commonly prescribed in the treatment of depression, generalized anxiety disorder, obsessive compulsive disorder and other conditions.

Cymbalta (Duloxetine) is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI) commonly prescribed to treat depression, general anxiety disorder, fibromyalgia, diabetic neuropathy and other conditions.

Taking Lexapro along with Cymbalta can increase the risk of serious condition called the serotonin syndrome which is characterized by confusion, hallucination, seizures, high BP, increased heart rate, fever, excessive sweating, shivering, blurred vision, muscle rigidity, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea.

In severe cases result coma and even death may occur. You should seek immediate medical attention if you experience these symptoms while taking the medications.

Her treating doctor was already aware of the risks, so consult him/her again for proper clinical evaluation and use of a safer medication to control your daughter's problem.

Hope this will solve her problem.

A feed back is appreciated.
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What Are The Side Effects Of Taking Lexapro And Cymbalta Together?

Hi & Welcome. Taken together they may cause a harmful interaction. Incomplete data like age, purpose of taking the medications??? Lexapro (Escitalopram) is a selective serotonin reuptake inhibitor (SSRI) commonly prescribed in the treatment of depression, generalized anxiety disorder, obsessive compulsive disorder and other conditions. Cymbalta (Duloxetine) is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI) commonly prescribed to treat depression, general anxiety disorder, fibromyalgia, diabetic neuropathy and other conditions. Taking Lexapro along with Cymbalta can increase the risk of serious condition called the serotonin syndrome which is characterized by confusion, hallucination, seizures, high BP, increased heart rate, fever, excessive sweating, shivering, blurred vision, muscle rigidity, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. In severe cases result coma and even death may occur. You should seek immediate medical attention if you experience these symptoms while taking the medications. Her treating doctor was already aware of the risks, so consult him/her again for proper clinical evaluation and use of a safer medication to control your daughter s problem. Hope this will solve her problem. A feed back is appreciated.