What can cause high heart rate considering I have a diagnosis of JRA? I am 37 years old, have had JRA since age 5 and am now experiencing a very fast heart rate. My HR has always been a little high but now it is running between 120 at rest and 168 with minimal activity. All bloodwork is normal (potassium, magnesium, etc), EKG and ECHO are normal. Holter monitor showed normal except for high heart rate. HR has been this way for about 2 1/2 weeks now. Cardium has not helped. As soon as I stand up, blood pressure drops and HR increases. I become short of breath after walking only 10-15 feet. I m not getting answers from Drs and am getting more and more concerned.