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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes An Increase In AST/ALT Levels?

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I recently had a liver panel drawn. Everything was within normal range except AST/ALT. My AST was121, and my ALT was 92. I have been taking sertraline for about 10 years. I don't know if that could have any effect on these levels. I also have hemochromatosis that is being treated with phlebotomies.





Thank you,



Sherry Sparrow
Fri, 11 Mar 2016
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Gastroenterologist,  's  Response
Hello! Thanks for putting your query in HCM. I am a Gastroenterologist.

Sertraline do not cause any effect on liver. Hemochromatosis may cause elevation.

Increase in AST and ALT has many other cause like Hepatitis B, C, Metabolic disorders, NAFLD, alcohol intake etc. So I will suggest you to visit a Hepatologist for evaluation who will advise tests and then manage accordingly.

Meanwhile there are few medicines which I found very useful in my patients are ursodeoxycholic acid and vitamin E. Do regular exercise and reduce your weight if you are overweight, avoid alcohol if you drink.I hope I have answered your query and this will help you . Wish you a good health
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What Causes An Increase In AST/ALT Levels?

Hello! Thanks for putting your query in HCM. I am a Gastroenterologist. Sertraline do not cause any effect on liver. Hemochromatosis may cause elevation. Increase in AST and ALT has many other cause like Hepatitis B, C, Metabolic disorders, NAFLD, alcohol intake etc. So I will suggest you to visit a Hepatologist for evaluation who will advise tests and then manage accordingly. Meanwhile there are few medicines which I found very useful in my patients are ursodeoxycholic acid and vitamin E. Do regular exercise and reduce your weight if you are overweight, avoid alcohol if you drink.I hope I have answered your query and this will help you . Wish you a good health