I am a hospice nurse and have a patient that has breast cancer with mets to the pleura, pericardium and the lungs, has dealt with severe constipation for 10 years of battling her disease, when I took her on she was severely impacted, we have done colon cleanses, suppositories, enemas, and she is n a lengthly bowel regimen of linzess, miralax, and senna-s and still has episodes of severe diarrhea/constipation, bloating, gas and severe abdominal pain, gastro enterologist states she is problably still impacted can you suggest anything to get her comfort.