Hello, and I hope I can help you today. Amitriptyline is an antidepressant medication which really does not have any effect on your hormones or ability to conceive. However this medication is known to have an increased risk associated with birth defects, and for this reason, is not recommend to be taken during pregnancy. So it is unlikely that your fertility issues that you have at this point are caused by either of the medications that you take for depression. I recommend if you have not yet done so that you consult with an OB/GYN physician or fertility specialist for evaluation. Even if you or and your partner have both had children previously, that does not mean that new problems can develop with one or both of you. A preliminary hormonal evaluation of you and a test of your husband sperm should be performed at this point. You also should consider discussing your impending pregnancy with your psychiatrist and possibly trying to switch to a medication that can be used more safely during pregnancy. So in summary, I do not believe that your psychiatric medications are actually the cause of your fertility problem, however it would be a good idea to have a plan to switch off these medications as once you conceive they can put the baby at risk for birth defects. I hope I was able to adequately answer your question today, and that this information was helpful. Best wishes, Dr. Brown