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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Elevated Liver Enzymes?

Last check up I had enzyme levels of AST 121 and ALT of 114. Very much outside the normal range. I have been taking 3 advil PMs at bed time. ----along with several glasses of wine. I hear that wine can cause elevated enzymes but am curious if Advil/ benedryl will also cause a problem. Thinking of taking just benedryl. Doc says I mainly need to lose about 20 to 30 pounds (6Ft and 260 pounds now). Appreciate your comments. Note that typically my above enzyme levels run about 50 to 60.
Mon, 10 Apr 2023
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General & Family Physician 's  Response
Hi,

Elevated liver enzymes, specifically AST (aspartate aminotransferase) and ALT (alanine aminotransferase) are often indicative of liver damage or injury. A wide range of factors can contribute to elevated enzyme levels, including heavy alcohol consumption, medication use, hepatitis infections, autoimmune diseases, and fatty liver disease, among others.

In your case, both Advil PM and wine consumption can contribute to elevated liver enzymes. Advil PM contains ibuprofen, which is known to be hard on the liver, particularly when taken in large doses or over an extended period. Similarly, consuming excessive amounts of alcohol can damage the liver, leading to elevated enzyme levels.

It's important to note that elevated liver enzymes are not a diagnosis in and of themselves but rather a symptom of an underlying condition. Therefore, it's crucial to follow up with your doctor and undergo further testing to determine the cause of the elevated levels. Losing weight, as suggested by your doctor, can also help improve liver function and reduce the risk of liver damage.

Take care. Hope I have answered your question. Let me know if I can assist you further.

Regards,
Dr. Priyanka, General & Family Physician
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What Causes Elevated Liver Enzymes?

Hi, Elevated liver enzymes, specifically AST (aspartate aminotransferase) and ALT (alanine aminotransferase) are often indicative of liver damage or injury. A wide range of factors can contribute to elevated enzyme levels, including heavy alcohol consumption, medication use, hepatitis infections, autoimmune diseases, and fatty liver disease, among others. In your case, both Advil PM and wine consumption can contribute to elevated liver enzymes. Advil PM contains ibuprofen, which is known to be hard on the liver, particularly when taken in large doses or over an extended period. Similarly, consuming excessive amounts of alcohol can damage the liver, leading to elevated enzyme levels. It s important to note that elevated liver enzymes are not a diagnosis in and of themselves but rather a symptom of an underlying condition. Therefore, it s crucial to follow up with your doctor and undergo further testing to determine the cause of the elevated levels. Losing weight, as suggested by your doctor, can also help improve liver function and reduce the risk of liver damage. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician