My son is in stage 4 metatastic melanoma and was prescribed Mekinist 2 mgs. twice a day and taflinlar twice a day. Samples. When his prescription assistance was approved and the drugs came in the mail, the dosage for mekinist was 2 mgs. once a day and taflinar once a day. He is now taking the medication once a day for both. However, he, for the past couple of days has had a fever pushing 103. It has broken, but he still has a slight fever. He has had shortness of breath and dizziness. Now he has developed a wicked rash on his leg. He had groin tumor removal. I told him to take Benadryl. He also has severe bipolar, which is under control with numerous medications. I guess the best thing to do is call the cancer center in the morning. I am concerned that they overdosed him the first time. Any suggestions?