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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Inflammation On The Face After Applying Fluorouracil Cream?

I m on day eight of 5%fluoroucil cream and my face is very red and splotchy. no skin cancer just plenty of actinic keratosis. Originally my nurse practitioner recommended 2 weeks but I ve since read that for AK treatment 2 weeks might be overkill . I ll call her tomorrow but Im feeling like I m about done. what can you say without looking at me? Bo
Tue, 12 Jun 2018
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General & Family Physician,  's  Response
Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice.
I have read your post and understand your concern.
Fluorouracil cream could cause side effects namely skin irritation, burning, redness, dryness, pain, swelling, tenderness, or changes in skin color at the site of application.
To overcome it, you can take an antihistamine tablet like Levoceterizine once a day and locally apply moisturizer cream or lotion. Kindly avoid contact of the inflamed part with hot water and avoid exposure of the inflamed region to direct sunlight. Gradually, the symptoms should subside and your skin should be back to normal.
Hope the information provided helps.
All the best.
Regards,
Dr.Ashakiran.S.
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What Causes Inflammation On The Face After Applying Fluorouracil Cream?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. I have read your post and understand your concern. Fluorouracil cream could cause side effects namely skin irritation, burning, redness, dryness, pain, swelling, tenderness, or changes in skin color at the site of application. To overcome it, you can take an antihistamine tablet like Levoceterizine once a day and locally apply moisturizer cream or lotion. Kindly avoid contact of the inflamed part with hot water and avoid exposure of the inflamed region to direct sunlight. Gradually, the symptoms should subside and your skin should be back to normal. Hope the information provided helps. All the best. Regards, Dr.Ashakiran.S.