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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Lack Of Improvement In Endometrium Despite Increasing Dosage Of Estrogen?

i am undergoing endometrium testing for fet this is my third cycle but endometrium not improving inspite of increasing dose of estrogen in childhood i suffer from tb and two yr back before starting ivf i took six mnth att course tbpcr rrmain negative one yrs back can i undergo pcr once more or restart att emparically
posted on Wed, 26 Aug 2015
Twitter Fri, 15 May 2020 Answered on
Twitter Thu, 21 May 2020 Last reviewed on
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General Surgeon,  's  Response
Hello,

As per my clinical experience, the lack of improvement in endometrium despite increasing doses of estrogen indicates insult to the uterine endometrium. The underlying cause may be related to uterine fibrosis, adhesions through Asherman syndrome, tuberculosis or other chronic inflammation. In my clinic, I do recommend an endometrial biopsy for best possible evaluation and further guidelines accordingly.

Hope I have answered your question. Let me know if I can assist you further.

Regards,
Dr. Bhagyesh V. Patel, General Surgeon
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What Causes Lack Of Improvement In Endometrium Despite Increasing Dosage Of Estrogen?

Hello, As per my clinical experience, the lack of improvement in endometrium despite increasing doses of estrogen indicates insult to the uterine endometrium. The underlying cause may be related to uterine fibrosis, adhesions through Asherman syndrome, tuberculosis or other chronic inflammation. In my clinic, I do recommend an endometrial biopsy for best possible evaluation and further guidelines accordingly. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Bhagyesh V. Patel, General Surgeon