Hi, Loss of appetite and fatigue can have many physical and psychological causes. Some of the common causes include: - Stress and anxiety: High stress and anxiety levels can lead to loss of appetite and fatigue. - Depression: Depression can cause a decrease in appetite and energy levels. - Chronic illnesses: Chronic illnesses such as diabetes, thyroid disorders, and cancer can cause fatigue and loss of appetite. - Medications: Some medications can cause loss of appetite and fatigue as side effects. - Poor nutrition: A diet lacking essential nutrients can cause fatigue and poor appetite. In your case, it is important to determine the underlying cause of your symptoms before starting any treatment. If you have ruled out any underlying medical conditions, there are a few things you can try to improve your appetite and gain weight: Eat smaller, more frequent meals: Eating smaller meals more often can help increase your appetite and make it easier to consume more calories throughout the day. Choose nutrient-dense foods: Foods that are high in calories and nutrients, such as nuts, seeds, avocados, and fatty fish, can help you gain weight and improve your overall health. Exercise regularly: Regular exercise can help increase your appetite and build muscle mass, which can contribute to weight gain. Consider working with a nutritionist: A nutritionist can help you develop a meal plan that meets your nutritional needs and helps you achieve your weight gain goals. It is important to note that supplements such as Nutrigain powder should only be used under the guidance of a healthcare provider or registered dietitian. These supplements can be helpful for some people, but they are not a substitute for a healthy diet and lifestyle. If your symptoms persist or worsen or have any concerns about your health, it is important to seek medical attention. Your healthcare provider can help you determine the underlying cause of your symptoms and develop an appropriate treatment plan. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician