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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Low INR Levels While On Levetiracetam And Doxycycline?

Thanks.I am taking 6 milograms per day of cumidum for my artificial heart valve.I am also being given Levetiracetam for a mild seizure I had, and temporarily taking some Doxycycline , for a little infection in my nose. My blood thinness is at 4.7 while the range should be from 2.5 to 3.5. So y9ou think this because of the Levetiracetam? Mark Lindell
Wed, 6 Sep 2017
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Hematologist,  's  Response
Hi Mark,
Doxycyclin enahances the effect of blood thinners, hence the INR has gone up. Please check for the interactions before taking any new medicine.
Now stop blood thinner also for 2-3 days, and repeat INR after that. If it is between 2.5 and 3.5 continue with previous dose.
Levetiracetum has no interaction with the blood thinner, so you can safely continue it.
Hope I have answered your question. If you have any further question, I will be happy to help.
With regards,
Dr. Girish Kamat
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What Causes Low INR Levels While On Levetiracetam And Doxycycline?

Hi Mark, Doxycyclin enahances the effect of blood thinners, hence the INR has gone up. Please check for the interactions before taking any new medicine. Now stop blood thinner also for 2-3 days, and repeat INR after that. If it is between 2.5 and 3.5 continue with previous dose. Levetiracetum has no interaction with the blood thinner, so you can safely continue it. Hope I have answered your question. If you have any further question, I will be happy to help. With regards, Dr. Girish Kamat