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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Mood Swings And Fatigue While On Coreg, Plavix And Crestor?

I HAD BEEN TAKING PREMARIN 1.25 S FOR PAST 30 YEARS UP TO 4/17 WHEN I HAD A TIA. DOCTOR SAID TO GO OFF PREMARIN, SO I DID. HAD HIGH BLOOD PRESSURE ALSO FOR 30+ YEARS. HEART DISEASE WAS WAS MY FATHER S ISSUE. I THEN HAD A HEART STENT ON lABOR DAY AND ANOTHER AT THE END OF NOVEMBER. AM ON COREG, LISINOP, PLAVEX,ISOSORBIDE MONONITRATE,SPIRONOL LACTIONE,CRESTOR,LEVOTHYROXINE, AND A BABY ASPRIN. I AM EXPERIENCING HOT & COLD FLASHES, MOOD SWINGS AND OFF & ON TIREDNESS. TAKE AMBIEN AT NIGHT TO SLEEP. QUESTION...SHOULD I VISIT MY GYNOC AND ASK FOR .625 PREMARIN TO WEAN OFF? I BELIEVE THIS IS MY PROBLEM. THANK YOU. KAROL
posted on Wed, 24 Jan 2018
Twitter Wed, 27 Jun 2018 Answered on
Twitter Thu, 28 Jun 2018 Last reviewed on
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General & Family Physician,  's  Response
Hello and Welcome to ‘Ask A Doctor’ service.

I have reviewed your query and here is my advice.

The hot & cold flashes, mood swings, tiredness, insomnia might be signs of hyperthyreosis as you are using levothyroxine, but these are also some of the side effects of premarin use.

In my opinion first af all you should do a blood check of thyroid hormones, and consult an endocrinologist.
If thyroid is normal then you can ask the gynecologist about discontinuing premarin.

Hope I have answered your query.

Let me know if I can assist you further.
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What Causes Mood Swings And Fatigue While On Coreg, Plavix And Crestor?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. The hot & cold flashes, mood swings, tiredness, insomnia might be signs of hyperthyreosis as you are using levothyroxine, but these are also some of the side effects of premarin use. In my opinion first af all you should do a blood check of thyroid hormones, and consult an endocrinologist. If thyroid is normal then you can ask the gynecologist about discontinuing premarin. Hope I have answered your query. Let me know if I can assist you further.