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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Nausea And Vomiting While On Azithromycin And Prednisone?

Hi, My name is Rustin Crocker. I was recently prescribed azithromycin and prednisone, aswell as an inhaler with albutrol sulfate for chest congestion and i had multipe adverse reactions to my stomach such as vomiting, watery diarrhea, nausea, and stomach pain/burning (felt highly acidic) . I told my doctor and she changed my prescription to levofloxacin. Is it less harsh on my stomach than the azithromycin? Is there an antibiotic that you would recommend instead? Multiple medical websites list this combination of prednisone (corticosteroid) and Levofloxacin (antibiotic) as drugs that have a major reaction together, this combination is labeled as clinically significant, and says that the risks outweigh the benifits. Why am i prescribed two drugs that shouldn t be taken together. If taken separately at different times of day how long should i wait in between to stagger the doses for less risk factor? I was told by the pharmacist that these side effects (doctor believed to be caused by the azithromycin) are very common, while the box says diarrhea(4-5%) stomach pain (2-3%) and that less than 1 % (cdc study shows .7%) of patients stopped taking the drug due to side effects. Should i trust the pharmacist (that has a minimum of 6 years of education on drugs) or the doctor (that has more medical education but less specifically directed)?
Thu, 12 May 2016
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Dentist 's  Response
Hi Dear,

Welcome to HCM.

Understanding your concern. As per your query you have symptoms of s nausea and vomiting while on Azithromycin and Prednisone . Well the symptoms you mention in query can occur due to many reasons like food poisoning , food allergy , infection of digestive system , gas , acid reflux , stomach flu or side effects of certain medicine so discuss it with doctor .You should take oral rehydration solution as well. I would suggest you to sips of water or other clear fluids on a very frequent basis. You should avoid solid foods for a few hours try small amounts of mild foods such as rice, applesauce and do not take foods or drinks caffeine , carbonated beverages , citrus and dairy products. If condition doesn't get better then consult gastroenterologist for proper examination and get complete examination done. Doctor may prescribe antiemetic drug , proton pump inhibitor and antacid . Drink green tea.

Hope your concern has been resolved.

Get Well Soon.

Best Wishes,
Dr. Harry Maheshwari
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What Causes Nausea And Vomiting While On Azithromycin And Prednisone?

Hi Dear, Welcome to HCM. Understanding your concern. As per your query you have symptoms of s nausea and vomiting while on Azithromycin and Prednisone . Well the symptoms you mention in query can occur due to many reasons like food poisoning , food allergy , infection of digestive system , gas , acid reflux , stomach flu or side effects of certain medicine so discuss it with doctor .You should take oral rehydration solution as well. I would suggest you to sips of water or other clear fluids on a very frequent basis. You should avoid solid foods for a few hours try small amounts of mild foods such as rice, applesauce and do not take foods or drinks caffeine , carbonated beverages , citrus and dairy products. If condition doesn t get better then consult gastroenterologist for proper examination and get complete examination done. Doctor may prescribe antiemetic drug , proton pump inhibitor and antacid . Drink green tea. Hope your concern has been resolved. Get Well Soon. Best Wishes, Dr. Harry Maheshwari