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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Non-hodgkin's Lymphoma?

I have relapsed non-hodkins lymphoma, and am not currently in treatment. Watch and waiting right now. I am having increased abdominal pain and very low body temperature -- under 91. Wondering whether my spleen is enlarged or whether other possibility. I know this is complicated and I need to go to oncologist on Monday. Thanks.
posted on Fri, 14 Mar 2014
Twitter Mon, 4 May 2015 Answered on
Twitter Tue, 5 May 2015 Last reviewed on
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Radiologist,  's  Response
Hi,
Thanks for writing in.

Non Hodgkins lymphoma is due to the uncontrolled proliferation of cancer cells which have altered DNA changes which are usually acquired after birth. Such acquired changes may result from exposure to radiation, cancer-causing chemicals, or infections, but often these changes occur for no apparent reason. Its incidence increases with age. It involves enlargement of spleen and lymphnodes.

Among the common cell mutations that are seen in non hodgkins lymphoma, most cases of follicular lymphoma (a type on non hodgkins lymphoma) have a translocation between chromosomes 14 and 18, which turns on the bcl-2 oncogene. This stops the cell from dying at the right time, which can lead to lymphoma due to proliferation. Please do not worry.
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What Causes Non-hodgkin's Lymphoma?

Hi, Thanks for writing in. Non Hodgkins lymphoma is due to the uncontrolled proliferation of cancer cells which have altered DNA changes which are usually acquired after birth. Such acquired changes may result from exposure to radiation, cancer-causing chemicals, or infections, but often these changes occur for no apparent reason. Its incidence increases with age. It involves enlargement of spleen and lymphnodes. Among the common cell mutations that are seen in non hodgkins lymphoma, most cases of follicular lymphoma (a type on non hodgkins lymphoma) have a translocation between chromosomes 14 and 18, which turns on the bcl-2 oncogene. This stops the cell from dying at the right time, which can lead to lymphoma due to proliferation. Please do not worry.