Hi, Welcome to Ask A Doctor service. I have read your question and here is my advice. Pain of arthritis may be troublesome. Duexis should not be used for long periods of time, however, the possible risk of stroke and heart attack are extremely rare with these drugs. Until used for very prolong durations, their adverse effects are things you need not worry about. There is rarely any problem with its short term use. Prolonged usage, like using it for months to years at a time, may cause many problems. I hope I have answered your question. I would be glad to answer any further question if you have. Regards, Dr. Rahman