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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Recurring Miscarriages In A Woman With PCOD?

Hi doctor, am 27 yrs old,married before 3 yr.Got pregnant 3 times, but unfortunately miscarried 3 times on 1st tri semester.Last one happened before 3 months, and that time i took clomid,metformin (bcoz i have pcod)nd aspirin.Also projestrone injections during my pregnancy. Doctors have no reason abt my m/c.Can u pls tell me,wat could be the possible reasons of m/c?Is it due to pcod?And i want to conceive after 2 months.So what all are steps i will have to take before getting pregnant?
posted on Sat, 20 Feb 2016
Twitter Tue, 10 May 2016 Answered on
Twitter Wed, 11 May 2016 Last reviewed on
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General & Family Physician,  's  Response
Hello dear
Under stand your concern
Pathophysiology of miscarriage is remain unclear. There is multiple hypothesis for that. Main reason is the insulin resistance and hyperinsulinemia. Other mechanism are as follows that are also directly linked with hyperinsulinemia.
Abnormal development of endometrium during implantation, obesity, increased activity of plasminogen inhibitor and protein C resistance lead to vascular uteroplacental insufficiency, abnormal gonadotropin hormone secretion, increased uterine vascular Resistance.
So main aim is to reduce insulin resistance:Start exercise, maintain weight, and continue on metformin, inositol, clomiphane and aspirin.
Once you become pregnant: gynecologist may provide: gonadotropin hormone, ovulation induction medicine, HCG and progesterone to support pregnancy.
Laproscopy may be helpful in some case of PCOS. Avoid constipation and stress.
Hope this may help you
Best regards
Dr. Sagar

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What Causes Recurring Miscarriages In A Woman With PCOD?

Hello dear Under stand your concern Pathophysiology of miscarriage is remain unclear. There is multiple hypothesis for that. Main reason is the insulin resistance and hyperinsulinemia. Other mechanism are as follows that are also directly linked with hyperinsulinemia. Abnormal development of endometrium during implantation, obesity, increased activity of plasminogen inhibitor and protein C resistance lead to vascular uteroplacental insufficiency, abnormal gonadotropin hormone secretion, increased uterine vascular Resistance. So main aim is to reduce insulin resistance:Start exercise, maintain weight, and continue on metformin, inositol, clomiphane and aspirin. Once you become pregnant: gynecologist may provide: gonadotropin hormone, ovulation induction medicine, HCG and progesterone to support pregnancy. Laproscopy may be helpful in some case of PCOS. Avoid constipation and stress. Hope this may help you Best regards Dr. Sagar