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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Seizure While On Allopurinol?

I hadn t had a seizure in over 26 years, I had suffered with flare ups of gout for a long time in hands feet elbows knees shoulder recently I was given allopurinol at 300 mg and took it for several weeks also was prescribed a 8 week course of cholchazine to treat the thophi on the feet and fingers, the course of cholchazine has finished by 1 week. During a gout acute flare up this dose was increased from 300 to 600 mg of allopurinol on this same day I had a seizure. could the change in medication of caused my seizure.
Tue, 21 Feb 2017
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General & Family Physician,  's  Response
Hi,


I admire your positive outlook and congratulate you for the attitude



Now I guess you have seizure as your main symptom



There are lots of pathological causes responsible for your problems but before going to it let me clarify the dose of Allopurinol. Usually at hospital we give patients Initially, 100 mg daily, then adjusted according to serum uric acid concentration and for maintenance: Mild cases 100-300 mg daily; moderately to severe cases: Up to 600 mg daily. And Maximum: 900 mg/day can be given. Doses over 300 mg daily should be taken in divided doses. So if you are prescribed 600 mg per day take 300 in the morning and 300 mg at bed time.



Secondly if dose changes suddenly there is a chance of seizure which is very rare indeed.

However, let me give my opinion on seizure here if you want to ruled out any other pathology.

As per your symptoms history is concerned and if I were your treating doctor I must advise you to do like this-

1)Do a CBC with differential and ESR

2)Do an MRI scan and get clinical examination done to ruled out any neurological deficit as well as

For this you need expert's guidance by your treating Neuro Doctor.

Hope this helps.
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What Causes Seizure While On Allopurinol?

Hi, I admire your positive outlook and congratulate you for the attitude Now I guess you have seizure as your main symptom There are lots of pathological causes responsible for your problems but before going to it let me clarify the dose of Allopurinol. Usually at hospital we give patients Initially, 100 mg daily, then adjusted according to serum uric acid concentration and for maintenance: Mild cases 100-300 mg daily; moderately to severe cases: Up to 600 mg daily. And Maximum: 900 mg/day can be given. Doses over 300 mg daily should be taken in divided doses. So if you are prescribed 600 mg per day take 300 in the morning and 300 mg at bed time. Secondly if dose changes suddenly there is a chance of seizure which is very rare indeed. However, let me give my opinion on seizure here if you want to ruled out any other pathology. As per your symptoms history is concerned and if I were your treating doctor I must advise you to do like this- 1)Do a CBC with differential and ESR 2)Do an MRI scan and get clinical examination done to ruled out any neurological deficit as well as For this you need expert s guidance by your treating Neuro Doctor. Hope this helps.