Hi, Pernicious anemia is a type of anemia that occurs due to the body s inability to absorb vitamin B12 properly. This can be caused by an autoimmune condition, in which the body s immune system attacks the cells in the stomach that produce a protein called intrinsic factor, which is needed for the absorption of vitamin B12. Without enough vitamin B12, the body cannot produce healthy red blood cells, which can lead to anemia. Seizures and migraines can be associated with pernicious anemia, although they are not direct consequences of the condition. Agenesis of the corpus callosum (ACC) is a developmental condition in which the band of nerve fibers that connects the two hemispheres of the brain is either partially or completely absent. ACC is a congenital condition, meaning it is present at birth and is not typically associated with pernicious anemia. However, certain neurological conditions can be associated with both pernicious anemia and seizures or migraines. For example, some individuals with pernicious anemia may develop neurological symptoms due to vitamin B12 deficiency affecting the nervous system, which can include peripheral neuropathy, ataxia, and cognitive impairment. Additionally, some genetic conditions can cause both ACC and seizures, such as Aicardi syndrome, which is characterized by the absence of the corpus callosum, seizures, and other neurological abnormalities. However, it is important to note that Aicardi syndrome is a rare condition, and not typically associated with pernicious anemia. Overall, it is important to work closely with your healthcare provider to determine the underlying cause of your seizures, migraines, and ACC, and to develop an appropriate treatment plan based on your individual needs and medical history. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician