What Causes Short Temper, Constant Agitated Behavior And Prolonged Heavy Menstruation?

Hi, my 15 year old daughter has always been strongwilled and dealt with anger issues but has been constant for a few years now. She was on Imiprimam from age 10-12 for night time incontinence and that is when it seemed to escalate. She has a pretty average life, no history of any kind of abuse, nothing substantial or out of the ordinary going on. Typical teenage life. She has stated that she doesnt know whats wrong and why she feels so angry so often. It has caused her to be able have very few friends and cause strife in all of her relationships. I have tried natural mood stabilizer herbs, we talk about things often nothing seems to help. She feels often as if she has no control of herself. I have been researching mental disorders and wondering about hormonal imbalances. She has very long heavy periods which during that she is more aggitated but it never goes away. It is daily and she flips on a dime, reacting to things that do not call for a response like she has.