Hi,
Sometimes some women may not get adjusted to
hormonal contraceptives.
According to the literature, unusual changes in vaginal bleeding like continuous spotting, excessive bleeding, weight gain, are the some of the side effects of Depo-
provera.
Response to medicine and development of side effects are subjective any may vary from person to person.
Usually after starting the hormonal contraceptive, it may take few months to get adjusted.
But as even after second dose, you are having the side effects, better to stop this and shift to any other contraceptive method with your doctor's advice.
Investigations like complete blood picture,
ultrasound,
thyroid profile, etc. will help in ruling out other causes of continuous spotting and weight gain.
Hope I have answered your query. Let me know if I can assist you further.
Take care
Regards,
Dr. Sree Gouri SR