I was diagnosed with systemic lupus at age 60. I m taking methotrexate, plaquenil, prednisone, 60 mg of Morphine & Norco. This combination of meds has allowed me to stay active--lots of quilting with friends and volunteer groups. Life has been good. Unfortunately, in the last few months, I ve had chronic swelling of my ankles, knuckles and other joints. In addition I m experiencing extreme fatigue which is stopping me from my favorite activities. This has lead to depression, of course. Is this a lupus flare ? If so, what can I do to relieve the symptoms? Thank you, Lynda