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What Causes Thin Membrane Disease?
thin membrane disaese , yong male patient presented with haemoptysis and haematurea no cast ,but albuminurea ., surprisingly renal biopsy done revealed diffuse segmental proliferative ,no antibody detected by immunofloursent micro. other lab investigation an physical examination were unremarkable . thanks
Thu, 30 Oct 2014
Hi,
The basement membrane is a sheet like structure in the kidneys where filtration of wastes takes place.
Thin-glomerular-basement-membrane nephropathy is a familial disorder with an autosomal dominant pattern of inheritance, characterized histologically by diffuse thinning of glomerular basement menbrane and clinically by microscopic hematuria.
One copy of the abnormal gene from either parent can cause this disease. Development of autosomal nonprogressive Thin-glomerular-basement-membrane nephropathy involves heterozygous mutations in either COL4A3 or COL4A4 genes.
The basement membrane is a sheet like structure in the kidneys where filtration of wastes takes place.
Thin-glomerular-basement-membrane nephropathy is a familial disorder with an autosomal dominant pattern of inheritance, characterized histologically by diffuse thinning of glomerular basement menbrane and clinically by microscopic hematuria.
One copy of the abnormal gene from either parent can cause this disease. Development of autosomal nonprogressive Thin-glomerular-basement-membrane nephropathy involves heterozygous mutations in either COL4A3 or COL4A4 genes.
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