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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Could Be The Reason For High C-reactive Protein?

My Father is 84 years old . He was diagnosed with Spine T.B on 27-10-13 . The M.R.I. Impression was – “ Infective Spondylodiscitis (involving Discs D12-L1 & D12 as well as L1 Body with anterior epidural collection as well as granulation tissue causing compression over theca & rightside nerve root . Para vertebral abscess on either side at D12 to L1-L2 level involving adjacent psoas muscle .Facet joint arthritis with disc generative changes seen at all lumbar level . Posterior marginal osteophytes at all lumbar level ” . He was operated for the same on 1-11-13 (D10-L3 Pedicle Screw Fixation & D12-L1 Left Transpedicular Corpectomy + Bone grafting) . After the Operation , he developed Hyponatremia & got a small seizure (just once in Hospital for which he was quickly treated) . His SGPT , SGOT & Creatinine levels were also very High . Pyrazinamide was stopped . SGPT , SGOT , Creatine & Sodium normalized by mid-December & for T.B. , he was put on treatment involving only Isoniazid , Rifampicin & Ethambutol which he took till 11-12-14 . Just before the Operation , his ESR was 1st Hr – 27 mm/hour (Normal 3 -5 mm/hr) , 2nd Hr – 55 mm/hr (Normal 7-15 mm/hr) . C Reactive Protein was 9 mg/L (Normal In November 2014 , he was diagnosed with Dengue Fever with Thrombocytopenia for which he was hospitalized for 12 days & cured . During this time , his Blood Thinning Medicine had to be stopped for 5 days . However , around 3 days after being discharged , he developed Acute Coronary Syndrome & was hospitalized in Cardiac Care for around 3 days . His Condition stabilized & he was discharged thereafter . Since then , he is visiting Cardiologist every 3 months with Lipid Profile & getting ECG & 2 D Echo done . His Heart Function details are as follows : Before & on 31-7-13 - 50 to 60 % 31-10-13 A Day before the Spine Operation) – 45 to 50 % 21-11-13 - 40 % 5-11-14 (On Admission into Hospital for Dengue) - 35 to 40 % 15-11-14 (On Admission into Hospital following Acute Coronary Syndrome) – 20 % 23-6-15 - 25 % On 2nd May 2015 , his Eldest Son (My elder Brother) , aged 57 , died due to Septic Shock following an infection with Streptococcus Pyogenes . His latest ECG (Dated 23-6-15) is as follows : 1100 – Sinus Rhythm 1570 – with Occasional ventricular premature complexes Wide QRS dur . ectopic beat with shortened RR int (beat 5) 2231 – First Degree AV Block (PR int = 210 ms) 3624 – Possible Inferior Myocardial Infarction , age undetermined ( abnormal Q (11) ) 9150 – abnormal ECG Latest E.S.R. (As on 23-6-15) - 17 mm/hr - 1str Hr( Normal 3 – 5) 33 mm/hr – 2nd Hr (Normal 7 – 15) . Latest W.B.C. Count (As on 23-6-15) – 6600 /cmm (Normal 4000 to 10,000) However , Latest , C Reactive Protein (As on 23-6-15) is 58 mg/Ltr MEDICAL & SURGICAL HISTORY – Suffered from Myocardial Infarction in 1995 . Bypass Surgery done with 5 arterial grafts - 3 on left & 2 on right side .Hypertension since 40 years . Hernia Operation done in 2002 & 2009 . PAST & CURRENT MEDICATION – Before Spine T.B. Operation - Becosule Tablet (Multi Vitamin) - 1-0-0 Cardace H5- 1-0-0- Ecosprin AV 75 (Atorvastatin 10 mg + Aspirin 75 mg) - 0-0-1 Evion 400mg (Vitamin E) - 0-0-1 Treatment for T.B. - Ethambutol Rifampicin Isoniazid Pyrazinamide 800 mg - 16 Days 600 mg - 22 Days 300 mg - 409 days 1500 mg - 22 Days 1000 mg - 84 Days 300 mg - 18 Days 450 mg - 60 Days 600 mg - 38 Days Current Medication - 1)Tab Ecosprin Gold 20(Atorvastatin 20mg,Aspirin 75mg,Clopidogrel 75mg) 0-0-1 2)Tab Monit SR (60) (Isosorbide Mononitrate 60 mg) 1-0-0 3)Tab Nikoran OD (10) (Nokirandil 10 mg) 1-0-0 4)Tab Cardace H5 (Ramipril 5mg, Hydrochlorothiazide 12.5mg ) 1-0-0 5)Tab Dytor 10 ( Torsemide10 mg) 0-1-0 6)Tab Amlodac 5 ( Amlodipine 5 mg) 1-0-1 7)Tab Thyronorm 75( Levothyroxine 75 mcg) 1-0-0 Allergies – Very Occasionally , he gets episode of Urticaria (Nettle rash) . At these times , he ingests the powder of a herb called Indian Madder . The Rash subsides in around 3-4 days . My Question is :- What could be the reason for such a High Value of C.Reactive Protein ?
Fri, 28 Aug 2020
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General & Family Physician 's  Response
Hi,

CRP is a rough indicator which is raised when there is an infection and inflammation going on in the body. It is a nonspecific entity. Your needs complete evaluation as he has multiple health issues. Your clinician would be the best guide.

Take care. Hope I have answered your question. Let me know if I can assist you further.

Regards,
Dr. Ajeet Singh, General & Family Physician
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What Could Be The Reason For High C-reactive Protein?

Hi, CRP is a rough indicator which is raised when there is an infection and inflammation going on in the body. It is a nonspecific entity. Your needs complete evaluation as he has multiple health issues. Your clinician would be the best guide. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Ajeet Singh, General & Family Physician