Hi,
Noted the history about your quadriplegic patient developing hard lumps near great toe and knee every morning which settles by afternoon, pressure wound being treated, on
protein supplements and high protein diet.
Since the lumps are hard in the morning, on the same spot and settle by afternoon, the commonest cause I can think about is FDR that is
fixed drug reaction, it is not necessarily the medicine but can be anything else like spices, preservatives in foods and medicines that cause the reaction.
This is sort of a
angioneurotic edema.
As the lumps ae formed only at two same spots again and again, give antihistamine and see the results.
Oral
steroid only if required.
To find out the foods, beverages, medicines, any other factors that cause such lumps and stop these altogether.
This does not look to be a serious matter.
Take care about the
pressure sores well.
It is always better to get the proper investigations of blood, urine and stool to know any problems which can then be treated specifically.
Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. T. Chandrakant, General Surgeon