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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Do My Blood Test And MRI Results Showing Mild Cortical Changes And A Slightly Elevated Hemoglobin A1C Mean, And Are They Serious?

Hello, I’m a 30 year old male; two months ago I suffered a little accident at my home (I was assembling a rack and a part of it hit the back of my head) but I didn’t have any serious symptoms of concussion just drowsiness, loss of balance/dizziness and pain behind my eyebrows. Just to be safe that my brain didn’t suffer at all due to this incident, I went to a doctor and he sent me to perform a blood test and an MRI. The blood test says that I have a 5.8% hemoglobin A1C. The MRI says the following “Mild age advanced cortical involutional changes are present, most pronounced in the biparietal regions”. What do these diagnostics mean? Are they serious? PD: I have never consumed alcohol in my life nor I’m a smoker.
posted on Mon, 18 Mar 2024
Twitter Thu, 25 Sep 2025 Answered on
Twitter Tue, 30 Sep 2025 Last reviewed on
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General & Family Physician,  's  Response
Hello,

Your result 5.8% falls in the prediabetic range, it means your blood sugar is slightly higher than normal but not yet in the diabetic range. Since you are at increased risk of developing type 2 diabetes, you are advised to exercise 30–45 mins daily, take balanced homemade food. Avoid taking refined sugar and maintain healthy weight. increase fiber in your diet.

Recheck in 3-4 months to see your blood sugar level, periodic monitoring is recommended. Cortical changes refer to mild shrinkage or thinning of the brain’s outer layer (cortex). In a few people, cortical thinning in parietal areas can show as slightly more, even in their 20s–30s. Mild cortical changes are influenced by chronic stress, sleep deprivation, or metabolic factors (like slightly elevated blood sugar) over time.

Have quality sleep of 8 hours, avoid stress both emotional and physical, and maintain your blood sugar level at all costs to prevent further complications. Since your only symptoms after the accident were mild drowsiness, dizziness, and headache behind the eyebrows, and there are no persistent neurological deficits, the MRI findings are not concerning. The recent accident has not caused serious injury. In the absence of neurological symptoms, your MRI finding is mild and not dangerous for your age.

Take care. Hope I have answered your question. Let me know if I can assist you further.

Regards,
Dr. Nupur K., General & Family Physician
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What Do My Blood Test And MRI Results Showing Mild Cortical Changes And A Slightly Elevated Hemoglobin A1C Mean, And Are They Serious?

Hello, Your result 5.8% falls in the prediabetic range, it means your blood sugar is slightly higher than normal but not yet in the diabetic range. Since you are at increased risk of developing type 2 diabetes, you are advised to exercise 30–45 mins daily, take balanced homemade food. Avoid taking refined sugar and maintain healthy weight. increase fiber in your diet. Recheck in 3-4 months to see your blood sugar level, periodic monitoring is recommended. Cortical changes refer to mild shrinkage or thinning of the brain’s outer layer (cortex). In a few people, cortical thinning in parietal areas can show as slightly more, even in their 20s–30s. Mild cortical changes are influenced by chronic stress, sleep deprivation, or metabolic factors (like slightly elevated blood sugar) over time. Have quality sleep of 8 hours, avoid stress both emotional and physical, and maintain your blood sugar level at all costs to prevent further complications. Since your only symptoms after the accident were mild drowsiness, dizziness, and headache behind the eyebrows, and there are no persistent neurological deficits, the MRI findings are not concerning. The recent accident has not caused serious injury. In the absence of neurological symptoms, your MRI finding is mild and not dangerous for your age. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Nupur K., General & Family Physician