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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Does Elevated CK And CKMB Level In Blood Mean?

My 6 year old son has had fevers on and off for no reason. Then last Tuesday his legs hurt him so bad he was walking on his tiptoes. I took him to doctors and they did ultrasound and it came back fine. Then they did blood work and called today and said he needs to see rheumatologist immediately because it shows high level of ck and ckmb. What does that mean?
Thu, 30 Apr 2015
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General & Family Physician 's  Response
Hi
Thanks for posting your concern on HCM.
I appreciate your concern for your son for the elevated CK and CK-MB.
Incomplete data: Exact level of CK and CK-MB not given.

In a 6 yr old child with no apparent heart disease, the elevated Creatine Kinase and Creating Kinase-MB are suggestive of skeletal muscle disease.

Damaged muscles release enzymes, such as CK and CK MB into the blood.

If CK-MB is elevated and the "relative index " (ratio of CK-MB to total CK) is less than 2, it suggests that skeletal muscles are damaged.

If CK-MB is elevated and the "relative index" is more than 3, it suggests the heart disease.

Inflammatory muscle diseases (myopathies) are rare.

Most commonly seen in young children between 5 to 10 yrs of age.
Causes include infection, muscle injury due to medicine, inherited diseases that affect muscle function, disorders of electrolyte levels, and thyroid disease.

You are advised to visit the rheumatologist for further evaluation may be your son needs a muscle biopsy to confirm or rule out muscle disease.

Hope this information could be of great help to you in getting the treatment for your son.
Wishing him good health.

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What Does Elevated CK And CKMB Level In Blood Mean?

Hi Thanks for posting your concern on HCM. I appreciate your concern for your son for the elevated CK and CK-MB. Incomplete data: Exact level of CK and CK-MB not given. In a 6 yr old child with no apparent heart disease, the elevated Creatine Kinase and Creating Kinase-MB are suggestive of skeletal muscle disease. Damaged muscles release enzymes, such as CK and CK MB into the blood. If CK-MB is elevated and the relative index (ratio of CK-MB to total CK) is less than 2, it suggests that skeletal muscles are damaged. If CK-MB is elevated and the relative index is more than 3, it suggests the heart disease. Inflammatory muscle diseases (myopathies) are rare. Most commonly seen in young children between 5 to 10 yrs of age. Causes include infection, muscle injury due to medicine, inherited diseases that affect muscle function, disorders of electrolyte levels, and thyroid disease. You are advised to visit the rheumatologist for further evaluation may be your son needs a muscle biopsy to confirm or rule out muscle disease. Hope this information could be of great help to you in getting the treatment for your son. Wishing him good health.