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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Does This Blood Test Result For Lupus Indicate?

Hello, I am currently undergoing blood tests to see if I have Lupus. I have a Positive ANA-Speckled Pattern-1:320 Titre. SED rate is 19 out of 0-20 reference point at the lab, low white blood count, negative single strand DNA, and still awaiting double strand result. I have the symptoms of redness on cheeks when I m in the sun for a while, fatigue, weak, joint and muscle pain, low fevers, headaches, and hair thinning. Also weight loss. Could this be Lupus even though a negative on single strand DNA?
posted on Mon, 31 Jul 2017
Twitter Wed, 9 Aug 2017 Answered on
Twitter Thu, 10 Aug 2017 Last reviewed on
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Nephrologist,  's  Response
Dear Patient,

a very strong index of activity is serum complement (C3 and C4). If these two proteins are low in the serum, it would be very likely that an individual has an immunocomplex mediated disease, in particolar lupus. However, in order to have a diagnosis (clinical) of lupus you should be investigated with the recently reviewed criteria by ACR (2015). Thus, only a comprensive analysis of all criteria may result in a diagnosis of lupus, although it is extremely unlikely to have SLE and a normal complement. Let me know, and take care
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What Does This Blood Test Result For Lupus Indicate?

Dear Patient, a very strong index of activity is serum complement (C3 and C4). If these two proteins are low in the serum, it would be very likely that an individual has an immunocomplex mediated disease, in particolar lupus. However, in order to have a diagnosis (clinical) of lupus you should be investigated with the recently reviewed criteria by ACR (2015). Thus, only a comprensive analysis of all criteria may result in a diagnosis of lupus, although it is extremely unlikely to have SLE and a normal complement. Let me know, and take care