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Thanks for contacting HCM with your health concern
1. Since you were taking 50 mcg of thyroxine earlier which now has been increased to 75 mcg and even then there is persistent elevation of
TSH levels thus could be poor response between patient and the drug, as such one needs to check with an
Endocrinologist [thyroid expert] to approach with problem of TSH evaluation.
2. If the levels are persistently elevated despite taking recommended dose and persistently adjusting the same then one should consider other causes like: heterophilic antibody interference, TSH secreting pituitary
tumor, or
thyroid hormone resistance syndrome.
3. Make sure that you are not missing/skipping the dose as it may result in fluctuation of Thyroid levels and also make sure to check with the dose mentioned on prescription and given by the Pharmacist [any mismatch]
4. As Iron and calcium [with supplements] interfere with the basorption of thyroxine thus make sure you are not taking any of these, likewise one may check with a Gastroeneterologist to exclude any
malabsorption syndrome [celiac disease]
PS. The best way is to increase the T4 dose and measure and balance upwards until the TSH and T4 levels normalize since even relatively large doses of
levothyroxine administered orally are less expensive and better tolerated that intravenous or intramuscular injections.